Researchers discovered that bowhead whales achieve extraordinary longevity and cancer resistance through highly efficient and precise DNA repair mechanisms. A whale-specific protein, CIRBP, enhances ...

Lantern Pharma (LTRN) announced the presentation of clinical data from its ongoing Phase 1 trial of LP-284 at the 25th Annual Lymphoma, Leukemia & ...

AI-advanced drug candidate achieves complete metabolic response after two cycles in patient who failed CAR-T and bispecific antibody therapies, validating LP-284’s mechanism of action. A novel ...

Vascular dysfunction in atherosclerosis and diabetes mellitus, as observed in the aging population of developed societies, is associated with vascular DNA damage and cell senescence. We hypothesized ...

The Summit supercomputer revealed how damaged strands of DNA are surgically repaired by a molecular pathway called nucleotide excision repair, or NER. NER’s protein components can change shape to ...

Abstract: Nucleotide excision repair (NER) is a key mechanism in cellular damage repair, and therefore in the cell's response to cisplatin treatment in neoplastic diseases. In this paper we suggest a ...

Effective maintenance, repair, and overhaul (MRO) practices are vital for reliable turbine operation. Innovative technologies such as artificial intelligence and 3D scanning are transforming MRO ...

Tumor-Infiltrating Lymphocyte Function Predicts Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Oxaliplatin forms part of routine treatment of advanced colorectal cancer; ...

The circadian clock regulates the daily rhythms in the physiology and behavior of many organisms, including mice and humans. These cyclical changes at molecular and macroscopic levels affect the ...

Activity of antibody-drug conjugates (ADCs) with radiation in preclinical bladder cancer models. This is an ASCO Meeting Abstract from the 2024 ASCO Genitourinary Cancers Symposium. This abstract does ...