The cohesin subunit Scc1 returns and reconstitutes the complex with Smc1–Smc3 in late mitosis upon DNA double-strand breaks, although it does not participate in homologous recombination-driven MAT ...
Three biochemical steps of the non-homologous DNA end-joining (NHEJ) process. This figure outlines the key stages of the NHEJ repair mechanism following DNA double-strand breaks. The process can be ...
Dynamic and Multi-Protein Nature of NHEJ Synapsis: NHEJ synapsis is highly dynamic and involves multi-protein assemblies that facilitate the precise alignment of broken DNA ends. Single-molecule ...
A community-based study found that despite current guidelines recommending that all patients diagnosed with epithelial ovarian cancer undergo testing for homologous repair deficiency (HRD), only about ...
A real-world study reveals the need for increased homologous repair deficiency and BRCA1/2 testing in patients with ovarian and breast cancers. Increased testing to identify patients with homologous ...
Your radiator is just as essential to your car’s operation as the engine itself. According to BookMyGarage, the farthest you can drive without a fully functioning radiator is about a quarter of a mile ...
The protooncoprotein N-Myc, which is overexpressed in approximately 25% of neuroblastomas as the consequence of MYCN gene amplification, has long been postulated to regulate DNA double-strand break ...
Jeffrey Tosoian presents a new tool in prostate cancer diagnosis with the development and validation of an 18-gene urine test designed to identify clinically significant prostate cancer published in ...
A recent study, undertaken by researchers at the Tokyo Metropolitan University and the Tokyo Metropolitan Institute of Medical Science (both Japan), unravels key steps in the process of homologous ...
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