If you are travelling Interstate 66, be aware that police are conducting enforcement efforts on all 76 miles in Virginia this weekend. In 2025, 456 people have died in traffic crashes on Virginia ...

CAPE GIRARDEAU, Mo. (KFVS) - “When you look at the interstate map of our country, you can see a glaring gap through from East to West and certainly right through Missouri,” said Cape Girardeau Mayor ...

Additional enforcement of traffic safety laws will be present on Interstate 66 over the weekend, according to Virginia State Police. Operation DISS-rupt will happen on all 76 miles of Interstate 66 on ...

A proposed Interstate 66 TransAmerica Corridor could revitalize Southeast Missouri by connecting rural communities to jobs, healthcare, and economic growth, addressing decades of regional isolation.